Journal article
Endovascular thrombectomy for ischemic stroke increases disability-free survival, quality of life, and life expectancy and reduces cost
BCV Campbell, PJ Mitchell, L Churilov, M Keshtkaran, KS Hong, TJ Kleinig, HM Dewey, N Yassi, B Yan, RJ Dowling, MW Parsons, TY Wu, M Brooks, MA Simpson, F Miteff, CR Levi, M Krause, TJ Harrington, KC Faulder, BS Steinfort Show all
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2017
Abstract
Background: Endovascular thrombectomy improves functional outcome in large vessel occlusion ischemic stroke. We examined disability, quality of life, survival and acute care costs in the EXTEND-IA trial, which used CT-perfusion imaging selection. Methods: Large vessel ischemic stroke patients with favorable CT-perfusion were randomized to endovascular thrombectomy after alteplase versus alteplase-only. Clinical outcome was prospectively measured using 90-day modified Rankin scale (mRS). Individual patient expected survival and net difference in Disability/Quality-adjusted life years (DALY/QALY) up to 15 years from stroke were modeled using age, sex, 90-day mRS, and utility scores. Level of c..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Supported by grants from the National Health and Medical Research Council of Australia (1043242, Bruce Campbell Fellowships 1035688 and 1111972 co-funded by Heart Foundation of Australia, Dominique Cadilhac fellowship 1063761 co-funded by Heart Foundation of Australia), Royal Australasian College of Physicians, Royal Melbourne Hospital Foundation, Stroke Foundation of Australia. Solitaire FR device and trial infrastructure were supported by an unrestricted grant from Covidien (Medtronic) who had no role in study design, conduct or analysis.